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2010 Dietary Guidelines Advisory Committee Systematic Reviews

Systematic Review Question

What effect does folic acid supplementation (with or without additional B vitamin supplementation) have on risk of CVD among persons with or without pre-existing vascular disease?

Conclusion Statement

Strong evidence demonstrates that folic acid supplementation with or without additional B vitamins in adult men and women with pre-existing vascular disease, does not appear to reduce risk of cardiovascular disease, and may increase risk slightly.

2010 DGAC Grade: Strong