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2010 Dietary Guidelines Advisory Committee Systematic Reviews

Systematic Review Question

What is the effect of dietary cholesterol intake on risk of cardiovascular disease?

Conclusion Statement

Moderate evidence from epidemiologic studies relates dietary cholesterol intake to clinical cardiovascular disease (CVD) end-points. Many randomized clinical trials on dietary cholesterol use eggs as the dietary source. Independent of other dietary factors, evidence suggests that consumption of one egg per day is not associated with risk of coronary heart disease or stroke in healthy adults, although consumption of more than seven eggs per week has been associated with increased risk. An important distinction is that among individuals with type 2 diabetes, increased dietary cholesterol intake is associated with CVD risk.

2010 DGAC Grade: Moderate